HIV and the oral microbiome

Background

Dental caries is the most common chronic disease in children, affecting nearly 42% of all children before the age of eleven. Untreated cavities are painful, can lead to problems with eating or speech development, and may even result in delayed learning outcomes for affected children. Currently as a postdoc at Clemson University, I am working on a longitudinal study of the oral microbiome of children living with HIV to better understand the impact of this chronic viral disease (and its treatment) on the oral microbiome. Using both metagenomics and metatranscriptomics our goal is to better understand the mechanisms driving oral health.

Relevant publications

Supragingival mycobiome of HIV-exposed-bu-uninfected children reflects a stronger correlation with caries-free associated taxa compared to HIV-infected or uninfected children. 2023. O’Connell LM, Mann AE, Osagie E, Akhigbe P, Blouin T, Soule A, Obuekwe O, Omoigberale A, Burne R, Coker MO, Richards VP. Microbiology Spectrum
Impact of HIV on the oral microbiome of children living in Sub-Saharan Africa, determined by using an rpoC gene fragment. metataxonomic approach. 2023. Mann AE, O’Connell LM, Osagie E, Akhigbe P, Obuekwe O, Omoigberale A, Kelly C, the DOMHaIN Study Team, Coker MO, Richards VP. Microbiology Spectrum
Dental caries and its association with the oral microbiomes and HIV in young children - Nigeria (DOMHaIN): a cohort study 2021. Coker MO, Akhigbe P, Osagie E, Idemudia NL, Igedegbe O, Chukwumah N, Adebiyi R, Mann AE, O’Connell LM, Obuekwe O, Omoigberale A, Charurat ME, Richards VP. BMC Oral Health

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Posters

Allison E. Mann, Ciara Aumend, Suzanne Crull, Lauren M. O’Connell, Esosa Osagie, Paul Akhigbe, Ozoemene Obuekwe, Augustine Omoigberale, Matthew Rowe, Thomas Blouin, Ashlyn Soule, Colton Kelly, the DOMHaIN Study Team, Modupe O. Coker, Vincent P. Richards. (2024) Childhood HIV infection and exposure impacts temporal and spatial assembly of the supragingival plaque microbiome. CUPDA Annual Research Symposium, Clemson University, Clemson, SC [PDF]. 2nd Place Winner!
Allison E. Mann, Lauren M. O’Connell, Esosa Osagie, Paul Akhigbe, Ozoemene Obuekwe, Augustine Omoigberale, Colton Kelly, the DOMHaIN Study Team, Modupe O. Coker, Vincent P. Richards. (2022) The impact of HIV on the oral microbiome of children and its relation to tooth decay. BioSci Research Expo, Clemson University, Clemson, SC [PDF]

Presentations

Coming soon!